Human Growth Hormone-Somatropin

 Growth Hormone As with no other doping drug,
growth hormones are still surrounded by an aura of mystery. Some call it a
wonder drug which causes gigantic strength and muscle gains in the shortest
time. Others consider it completely useless in improving sports performance and
argue that it only promotes the growth process in children with an early
stunting of growth. Some are of the opinion that growth hormones in adults cause
severe bone deformities in the form of overgrowth of the lowerjaw and
extremities. And, generally speaking, which growth hormones should one take the
human form, the synthetically manufactured version, recombined or genetically
produced form and in which dosage? All this controversy about growth hormones is
so complex that the reader must have some basic information in order to
understand them. The growth hormones is a polypeptide hormone consisting of 191
amino acids. In humans it is produced in the hypophysis and released if there
are the right stimuli (e.g. training, sleep, stress, low blood sugar level). It
is now important to understand that the freed HGH (human growth hormones) itself
has no direct effect but only stimulates the liver to produce and release
insulin-like growth factors and somatomedins. These growth factors are then the
ones that cause various effects on the body. The problem, however, is that the
liver is only capable of producing a limited amount of these substances so that
the effect is limited. If growth hormones are injected they only stimulate the
liver to produce and release these substances and thus, as already mentioned,
have no direct effect. The use of these STH somatotropic hormone compounds
offers the athlete three performance-enhancing effects. STH (somatotropic
hormone) has a strong anabolic effect and causes an increased protein synthesis
which manifests itself in a muscular hypertrophy (enlargement of muscle cells)
and in a muscular hyperplasia (increase of muscle cells.) The latter is very
interesting since this increase cannot be obtained by the intake of steroids.
This is probably also the reason why STH is called the strongest anabolic
hormone. The second effect of STH is its pronounced influence on the burning of
fat. It turns more body fat into energy leading to a drastic reduction in fat or
allowing the athlete to increase his caloric intake. Third, and often
overlooked, is the fact that STH strengthens the connective tissue, tendons, and
cartilages which could be one of the main reasons for the significant increase
in strength experienced by many athletes. Several bodybuilders and powerlifters
report that through the simultaneous intake with steroids STH protects the
athlete from injuries while inereasing his strength. You will say that this
sounds just wonderful. What is the problem, however since there are still some
who argue that STH offers nothing to athletes? There are, by all means, several
athletes who have tried STH and who were sadly disappointed by its results.
However, as with many things in life, there is a logical explanation or perhaps
even more than one: 1. The athlete simply has not taken a sufficient amount of
STH regularly and over a long enough period of time. STH is a very expensive
compound and an effective dosage is unaffordable by most people. 2. When using
STH the body also needs more thyroid hormones,insulin, corticosteroids,
gonadotropins, estrogens and what a surprise androgens and anabolics. This is
also the reason why STH, when taken alone, is considerably less effective and
can only reach its optimum effect by the additive intake of steroids, thyorid
hormones, and insulin, in particular. But we must point out in this case that
STH has a predominantly anabolic effect. There are three hormones which are
needed at the same time in order to allow for maximum anabolic effect. These are
STH, insulin, and an LT-3 thyroid hormone, such as, for example, Cytomel. Only
then can the liver produce and release an optimal amount of somatomedin and
insulin-like growth factors. This anabolic effect can be further enhanced by
taking a substance with an anticatabolic effect. These substances are-everybody
should probably know by now-anabolic/androgenic steroids or Clenbuterol. Then a
synergetic effect takes place.'Are you still wondering why pro bodybuilders are
so incredibly massive but, at the same time, totally ripped while you are not.
Most athletes have tried STH during preparation for a competition in that phase
when the diet is calorie-reduced. The body usually reacts by reducing the
release of insulin and of the L-T3 thyroid hormone. And, as was described under
point 2, this is not an advantageous condition when STH is expected to work
well. Well, we almost forgot. Those who combine Clenbuterol with STH, should
know that Clenbuterol (like Ephedrine) reduces the body's own release of insulin
and L-T3. True, this seems a little complicated and when reading it for the
first time it might be a little confusing; however it really is true: STH has a
significant influence on several hormones in the human body; this does not allow
for a simple administration schedule. As said, STH is not cheap and those who
intend to use it should know a little more about it. If you only want to burn
fat with STH you will only have to remember user information for the part with
the L-T3 thyroid hormone as is printed by Kabi Pharmacia GmbH for their compound
Genotropin: "The need of the thyroid hormone often inereases during treatment
with growth hormones." 3. Since most athletes vho want to use STH can only
obtain it if prescribed by a physician, the only supply source remains the black
market. And this is certainly another reason why some athletes might not have
been very happy with the effect of the purchased compound. How could he, if
cheap HCG was passed off as expensive STH? Since both compounds are available as
dry substances, all that would be needed is a new label of Serono's Saizen or
Lilly's Humatrope on the HCG ampule. It is no longer fun when somebody is paying
$200 for 5000 I.U. of HCG, only worth $ 12, and thinking that he just purchased
4 I.U. of STH. And if you think this happens only to novices and to the
ignorant, ask Ben Johnson. "Big Ben," who during three tests within five days
showed an above-limit testosterone level, was not a victim of his own stupidity
but more likely the victim of fraud. According to statistics by the German Drug
Administration, 42% of the HGH vials confiscated on the North American black
market are fakes. In addition to a display of labels in the Dutch or Russian
language the fakes are distinguished from the original product, in sofar as the
dry substance is not present as lyophilic but present as loose powder. The fakes
confiscated so far use the name "Humatrope 16" under the name of Lilly Company
(with Dutch denomination) or "Somatogen" (in Russian)." Nowhere can this much
money be made except by faking STH. Who has ever held original growth hormones
in his hand and known how they should look? 4. In a few very rare cases the body
reacts by developing antibodies to the exogenous STH, thus making it
ineffective. The question of the right dosage, as well as the type and duration
of application, is very difficult to answer. Since there is no
scientificresearch showing how STH should be taken for performance improvement,
we can only rely on empirical data, that is experimental values. The respective
manufacturers indicate that in cases of hypophysially stunted growth due to
lacking or insuffieient release of growt hormones by the hypophysis, a weekly
average dose of 0.3 I.U/ week per pound of body weight should be taken. An
athlete weighting 200 pounds, therefore, would have to inject 60 I.U. weekly.
The dosage would be divided into three intramuscular injections of 20 I.U. each.
Subcutaneous injections (under the skin) are another form of intake which,
however would have to be injected daily, usually 8 I.U. per day. Top athletes
usually inject 4-16 I.U./day. Ordinarily, daily subcutaneous injections are
preferred. Since STH has a half life time of less than one hour, it is not
surprising that some athletes divide their dail dose into three or four
subcutaneous injections of 2-4 I.U. each. Application of regular small dosages
seems to bring the most effective results. This also has its reasons: When STH
is injected, serum concentration in the blood rises quickly, meaning that the
effect is almost immediate. As we know, STH stimulates the liver to produce and
release somatomedins and insulin like growth factors which in turn effect the
desired results in the body. Since the liver can only produce a limited amount
of these substances, we doubt that larger STH injections will induce the liver
to produce instantaneously a larger quantity of somatomedins and insulin-like
growth factors. It seems more likely that the liver will react more favorably to
smaller dosages. If the STH solution is injected subcutaneously several
consecutive times at the same point of injection, a loss of fat tissue is
possible. Therefore, the point of injection, or even better, the entire sisde of
the body should be continuously, changed in order to avoid a loss of local fat
tissue (lipoathrophy) in the injection cell. One thing has manifested itself
over the years: The effect of STH is dosage-dependent. This means either invest
a lot of money and do it right or do not even begin. Half-hearted attempts are
condemned to failure Minimum effective dosages seem to start at 4 I.U. per day.
For comparison: the hypophysis of a healthy; adult, releases 0.5-1.5 I.U. growth
hormones daily. The duration of intake usually depends on the athlete's
financial resources. Our experience is that STH is taken over a prolonged
period, from at least six weeks to several months. It is interesting to note
that the effect of STH does not stop after a few weeks; this usually allows for
continued improvements at a steady dosage. Bodybuilders who have had positive
results with STH have reported that the build-up strength and, in particular,
the newly-gained muscle system were essentially maintained after discontinuance
of the product. It remains to be clarified what happens with the insulin and
LT-3 thyroid hormone. Athletes who take STH in their build-up phase usually do
not need exogenous insulin. It is recommended, in this case, that the athlete
eats a complete meal every three hours, resulting in 6-7 meals day. This causes
the body to continuously release insulin so that the blood sugar level does not
fall too low. The use of LT-3 thyroid hormones, in this phase, is carried out
reluctantly by athletes. In any case, you must have a physician check the
thyroid hormone level during the intake of STH. Simultaneous use of anabolic
/androgenic steroids and/or Clenbuterol is usually appropriate. During the
preparation for a competition the use of thyroid hormones steadily inereases.
Sometimes insulin is taken together with STH, as well as with steroids and
Clenbuterol. Apart from the high damage potential that exogenous insulin can
have in non-diabetics, incorrect use will simply and plainly make you "FAT! Too
much insulin activates certain enzymes which convert glucose into glycerol and
finally into triglyceride. Too little insulin, especially during a diet, reduces
the anabolic effect of STH. The solution to this dilemma? Visiting a qualified
physician who advises the athlete during this undertaking and who, in the event
of exogenous insulin supply, checks the blood sugar level and urine
periodically. According to what we have heard so far, athletes usually inject
intermediately-effective insulin having a maximum duration of effect of 24 hours
once a day. Human insulin such as Depot-H-Insulin Hoechst is generally used.
Briefly-effective insulin with a maximum duration of effect of eight hours is
rarely used by athletes. Again a human insulin such as H-Insulin Hoechst is
preferred. The undesired effect of growth hormones, the so-called side effects,
are also a very interesting and hotly-discussed issue. Above all it must be
said: STH has none of the typical side effects of anabolic/androgenic steroids
including reduced endogenous testosterone production, acne, hair loss,
aggressiveness, elevated estrogen level, virilization symptoms in women, and
increased water and salt retention. The main side effects that are possible with
STH are an abnormally small concentration of glucose in the blood (hypoglycemia)
and an inadequate thyroid function. In some cases antibodies against growth
hormones are developed but are clinically irrelevant. What about the horror
stories about acromegaly, bone deformation, heart enlargement, organ conditions,
gigantism, and early death? In order to answer this question a clear
differentiation must be made between humans before and after puberty. The growth
plates in a person continue to grow in length until puberty. After puberty
neither an endogenous hypersection of growth hormones nor an excessive exogenous
supply of STH can cause additional growth in the length of the bones. Abnormal
size (gigantism) initially goes hand in hand with remarkable body strength and
muscular hardness in the afflicted; later, if left untreated, it ends in
weakness and death. Again, this is only possible in pre-pubescent humans who
also suffer from an inadequate gonadal function (hypogonadism). Humans who
suffer from an endogenous hypersecrehon after puberty and whose normal growth is
completed can also suffer from acromegaly. Bones become wider but not longer.
There is a progressive growth in the hands and feet and enlargement of features
due to the growth of the lower jaw and nose. What the authorities like to do now
is to present extreme cases of athletes suffering from these malfunctions in
order to discourage others and to drum into athletes the fact that with the
exogenous supply of growth hormones they would suffer the same destiny. This,
however, is very unlikely, as reality has proven. Among the numerous athletes
using STH comparatively few are seven feet tall Neanderthalers with a protruded
lower jaw, deformed skull, claw like hands, thick lips, and prominent bone
plates who walk around in size 25 shoes. In order to avoid any
misunderstandings, we do not want to disguise the possible risks of exogenous
STH use in adults and healthy humans, but one should at least try to be
openminded. Acromegaly, diabpetes, thyroid insuficiency, heart muscle
hypertrophy, high blood ressure, and enlargement of the kidneys are
theoretically possible if STH is used excessively over prolonged periods of
time; however, in reality and particularly when it comes to the external
attributes, these are rarely present. Some athletes report headaches, nausea,
vomiting, and visual disturbances during the first weeks of intake. These
symptoms disappear in most cases even with continued intake. The most common
problems with STH occur when the athlete intends to inject insulin in addition
to STH. The substance somatropin is available as a dried powder and before
injecting it must be mixed with the enclosed solution-containing ampule. The
ready solution must be injected immediately or stored in the refrigerator for up
to 24 hours. It is usually recommended that the compound be stored in the
refrigerator. With the exception of the remedy Saizen the biological activity of
growth hormones is usually not impaired when storing the dry substance at 15-25
C (room temperature); however, a cooler place (2-8 C) is preferable.On the
black market the price for 4 I.U. each of the compounds Genotropin, Humatrope,
Norditropin, and Saizen, in Europpe is $80-120 for a prick-through vial
including the solution ampule. As already mentioned, there are many fakes. It is
noted that for the U.S.-American growth hormones compounds, the substance
content is not given in I.U.(International Units) but in mg (milligrams). Since
l mg corresponds to exactly 2.7 I.U. the 5mg solution of the compound Humatrope
by Lilly contains exactl 13.5 I.U. of Somatropin. The 10 mg solution of the
Protropin compound by the Genentech therefore contains 27 I.U. of Somatropin. In
American powerlifting and bodybuilding circles Humatrope is usually preferred
over Protropin. The reason is that Humatrope is synthesized from a chain of 191
amino acids and thus is identical to the amino acid sequence of the human growth
hormones. Protropin, on the other hand, consists of 192 amino acids, one amino
acid too many. This might be the explanation for why more antibodies are
developed with human growth hormone Protropin than with Humatrope. growth
hormones are on the doping list but they are not yet detectable during doping
tests.

Human growth hormone, as prepared for medical use. This is currently the most
expensive drug in use by athletes, so one should take special care when
acquiring this on the black market. A high percentage of these items turn out to
be relabeled HCG which bears a resemblance to GH. Some more unsterile and
dangerous counterfeits have also been reported. Growth hormone itself is very
delicate and is best stored at cool temperatures and used quickly. This is added
worry, even when purchasing legitimate GH, as the item may not have been handled
properly before purchase. Human growth hormone (hGH) is produced by somatotropes
in the pituitary gland of the human brain. Somatotropes make up more than 50% of
the pituitary gland and growth hormone is by far the most important hormone
produced there. By the age of 60 most people will have approximately 80% less
growth hormone in their system than when they were 20. Signs of GH reduction
include increased body fat, increased anxiety, social isolation, poor general
health, and lack of positive well being. GH has been the supplement of choice
for many professional athletes over the years. American football great, Lyle
Alzado, claimed that 80% of all professional American football players,
including himself, have taken GH. GH has amazing age-reversing effects that make
it possibly the strongest anabolic substance available. Some of the benefits
associated with GH supplementation include the reversal of common diseases
associated with aging, improved brain activity and function, it strengthens
connective tissue which reduces the probability of injury, incredible weight
loss without any loss in lean mass, reduces wrinkles by rejuvenating the skin,
it raises energy levels and brightens mood, promotes muscle growth, improves
libido, improves functions of the lungs which increases the level of oxygen in
the blood stream, provides immune system support and Thymus function, and
probably the most impressive characteristic is, its ability to produce more
muscle cells, something no steroid can do. There has been a lot of controversy
around GH and its effectiveness. While one athlete may make tremendous strides
toward his goal, another may see practically no improvement at all. This is
easily explained. Because GH is dosage-dependent, often times an athlete doesn't
use enough, long enough. A sufficient dose of GH can cost around $150-$170 per
day and a common black market price is around $20-$30 per I.U. making GH
possibly the most expensive supplement. Another misconception is that GH by
itself is the answer. GH by itself is practically useless. The real problem
isn't a lack of GH secretion but a lack of GH conversion in the liver. There are
two other hormones that are needed for maximum anabolic effect; insulin, and
Cytomel or other LT-3 thyroid hormone. This can be further enhanced by the
supplementation of other anticatabolic drugs such as steroids, Clenbuterol, or
an ephedrine based supplement. It is tough to find out what the most effective
dosages are. According to our sources, it is popular to use about .3 I.U./week
for each pound of body weight. For example a person weighing 200lbs. will need
60 I.U. per week. The dosages can be injected intramuscularly three times a week
broken into 20 I.U. injections. A more popular way to inject is subcutaneously
(under the skin and above the muscle) using 1/2" insulin needles. When injected
this way the dosage should be done daily in small intervals alternating to each
side of the body with each injection. American doctors often prescribe a dosage
of 2 I.U. per day, however a popular dosage is between 4-10 I.U. a day. When
injecting GH, it is important to not inject in the same area every time. Side
effects of GH are not at all the same as with anabolic and androgenic steroids.
Most common side effects are hypoglycemia (low blood sugar level) and inadequate
thyroid function. A huge misconception, brought on by the mass media, is that
Giantism is a common side effect of using GH in the normal human body. This is
only true if GH is used during the pre-pubescent period time in ones life. It is
very important that a person be completely full grown and mature before using
GH. Other rare side effects include diabetes, heart enlargement, high blood
pressure, and enlargement of the kidneys. The most common problem is not with
the injecting of GH, but the injecting of the insulin to go with it. Improper
injection of insulin can lead to serious problems. Growth Hormone comes from the
substance somatotropin which is available in a powder form as well. It must be
mixed with the solution that it comes with before it can be injected. It is
suggested that the solution be injected immediately or stored in the
refrigerator. Product Information Courtesy Pharma Group Product Name: SAIZEN
HUMATROPE International Name: - - Contents: 10 IU 72 IU Delivery: 2 vials 6
syringes 1 container - 3 mL Manufacturer: Serono Lilly Pharmacy Price: $
$ Active Substances: Somatropin Somatropin